Does Combining Kratom and Adderall Really Work?

Science experiment with plant

Kratom and Adderall are two substances that stimulate your central nervous system (CNS). In fact, they are some of the strongest CNS stimulants available in the market today. Therefore, combining these substances together can produce unbelievable effects in mood, motor functionality, and cognitive performance. But can the combination of both produce adverse side effects? This article discusses the drugs individually, as well as the pros and cons of combining the two substances together.

What is Adderall?

Adderall is the brand name of amphetamine, a drug used to treat narcolepsy (a chronic sleep disorder), attention deficit hyperactivity disorder (ADHD), and overeating. It also contains dextroamphetamine, a CNS stimulant.

Though Adderall has many therapeutic uses, it also possesses downsides including potential drug dependence, tolerance and abuse. In fact, its potential for psychological and physiological dependence is dangerously similar to cocaine and other illegal substances due to its euphoric and anorectic effects.

How does Adderall work?

Adderall (or amphetamine) works by increasing the availability of two neurotransmitters (norepinephrine and dopamine) in your CNS. As neurotransmitter levels increase, brain activity speeds up, leading to increased alertness and decreased fatigue. People suffering from ADHD take Adderall to help them focus with their studies and work. Side effects include depressed appetite and insomnia. At high doses, users have reported psychosis and convulsions. Due to these side effects, use of Adderall should be monitored closely and taken with caution.

What is Kratom?

Kratom is a plant native to Southeast Asian countries. Related to the coffee family of plants, it has a wide range of uses including as a painkiller, mood booster, and mind stimulant. At small doses it enhances your productivity, produces feelings of euphoria and promotes a sense of well-being. At higher doses, however, the plant produces deep sedative effects. For this reason, many people use this herbal medicine for chronic pain relief.

Similar to Adderall, the downsides of kratom include its potential for dependence, tolerance and abuse. As a result, the topic of Kratom is quite controversial and is banned in certain parts of the world. Still, millions of people around the world use this plant for chronic pain and opioid withdrawal relief.

How does Kratom work?

Two chemical compounds in kratom, mitragynine and 7-hydroxymitragynine, interact with opioid receptors in the brain, producing sedation, pleasure, and pain relief. Mitragynine can also interact with other brain receptors to produce stimulant effects (like the mu receptor). At small doses, users report increased sociability, energy, alertness and sense of well-being. At higher doses, kratom can cause sedation.

On a cautionary note, users have also reported feeling nauseous and vomiting after consuming high amounts of Kratom. Therefore, dosing is very important for safe and effective consumption of this plant.

Effects of combining Adderall and Kratom

Adderall and Kratom act as stimulants but in different ways. Adderall produces a sense of energy and helps the mind focus, hence enhancing productivity. Kratom creates a calming effect and supports relaxation. Both substances produce feelings of euphoria and contentment.

At low doses, the combination of both creates synergistic benefits. First, taking the two drugs together can induce greater euphoric effects and enhanced focus. Second, Kratom helps Adderall users combat the “crash” and feelings of anxiety associated with the regular use of Adderall. Third, Kratom helps maintain a good positive mood and avoid depression symptoms—another common side effect of Adderall. Lastly, Kratom helps manage Adderall-induced muscle pains. Overall, combining the two substances allows you to function confidently and productively without experiencing harsh side effects.

At higher doses, the combination of Kratom and Adderall produces a variation in effects. This is because at high doses Kratom induces sedative effects. On the other hand, high doses of Adderall causes insomnia. Many Reddit users, therefore, suggest taking Adderall and low doses of Kratom during the daytime. Green and white strains of Kratom are recommended during the daytime to potentiate the effects of Adderall. Users also suggest avoiding taking Adderall 4 to 6 hours before bedtime. Kratom can still be taken at nighttime to induce sleep. Red vein strains are suggested to induce relaxation and sleepiness.

Adderall side effects

Amphetamine and dextroamphetamine may cause the following side effects:

  • Anxiety
  • Restlessness
  • Reduced sex drive or ability
  • Insomnia
  • Body tremors
  • Fidgeting
  • Headaches
  • Dry mouth
  • Stomachaches
  • Chest pains
  • Nausea and vomiting
  • Diarrhea and constipation
  • Loss of appetite
  • Weight loss
  • Rapid heartbeats
  • Weakness in muscles
  • Seizures
  • Mania
  • Aggressive behavior
  • Difficulty seeing or blurred vision
  • Fever
  • Difficulty breathing or swallowing

Contraindications for Adderall

Adderall is contraindicated for patients with the following conditions:

  • Anxiety
  • Agitation
  • Glaucoma
  • Tourette’s syndrome or tics
  • Heart rhythm disorder
  • Coronary heart disease
  • myocardial infarction
  • Peripheral vascular disease
  • Congenital heart defect
  • Hypertension
  • Epilepsy
  • Schizophrenia

Mixing Adderall and Kratom: How to do it safely?

  • Let a doctor diagnose your mental and physical health prior to combining the drugs
  • Stay away from Adderall if you took MAO inhibitors within the last 14 days.
  • Monitor your Kratom and Adderall usage, the drug combination is a high risk for abuse and addiction.
  • Avoid snorting Adderall. It can cause nasal septum necrosis and severe respiratory problems.
  • Monitor your alcohol consumption in combination with the two drugs.


The mixture of Kratom and Adderall is highly dangerous. Although at low doses the effects appear to synergize with one another, it’s very difficult to control the exact measurement required for optimal effects. The side effects of Adderall are quite significant, and cannot be neutralized by Kratom in most cases. Also, since both drugs can cause severe dependence and tolerance, we recommend against combining Kratom with Adderall.

If you insist on combining the two substances, start with small doses and adjust the dosage according to your body’s reaction. Users of Adderall often talk about the “Adderall crash” that is experienced upon quitting the drug. The crash can make you feel sluggish, disconnected and disoriented. Therefore, we recommend you taper off Adderall slowly rather than stopping abruptly. This will reduce the severity of your withdrawal symptoms.

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